*Prices reflect U.S. average retail price

Duetact adjunct to diet and exercise in type 2 diabetes in patients already on pioglitazone + a sulfonylurea, or in patients on either pioglitazone or a sulfonylurea who need additional glycemic control.

Manufacturer's Website: Not Available                                                                                                                 Average retail cost: $379/month

Ertugliflozin (trade name Steglatro) is a drug for the treatment of type 2 diabetes. In the United States, it was approved by the Food and Drug Administration for use as a monotherapy and as a fixed dose combination with either sitagliptin or with metformin....Wikipedia

Manufacturer's Website: Segluromet                                                                                                                   Average retail cost: $413/month

Pioglitazone/metformin (also known by the brand names Actoplus Met, Piomet and Politor) is combination of two oral diabetes medications pioglitazone and metformin. The two oral antihyperglycemic agents with different mechanisms of action are used to improve glycemic control in patients with diabetes mellitus type 2...Wikipedia

Manufacturer's Website: Not Available                                                                                                        Average retail cost: $481/month

DPP-4 inhibitors combined with metformin include a sitagliptin/metformin combination and a saxagliptin combination (Komboglyze), and with alogliptin as Kazano among others...Wikipedia

Manufacturer's Website: Kombiglyze                                                                                                                 Average retail cost: $514/month

In 2013 the FDA approved the drug in three formulations: As a stand-alone with the brand-name Nesina. Combined with metformin using the name Kazano, and when combined with pioglitazone as Oseni... Wikipedia

Manufacturer's Website: Not Available                                                                                                                      Average retail cost: $531/month

Sitagliptin/metformin (trade name Janumet) is an anti-diabetic drug, being a combination drug of sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin...Wikipedia

Manufacturer's Website: Janumet                                                                                                                                Average retail cost: $570/month

Like other medications for the treatment of Type 2 diabetes, alogliptin does not decrease the risk of heart attack and stroke. Like other members of the gliptin class, it causes little or no weight gain, exhibits relatively little risk of causing hypoglycemia, and exhibits relatively modest glucose-lowering activity...Wikipedia

Manufacturer's Website: Not Available                                                                                                                   Average retail cost: $577/month

In Europe, Canada, and elsewhere metformin combined with linagliptin is marketed under the trade name Jentadueto...Wikipedia

Manufacturer's Website: Jentadueto                                                                                                                     Average retail cost: $630/month

In Europe, Canada, and elsewhere metformin combined with linagliptin is marketed under the trade name Jentadueto...Wikipedia

Manufacturer's Website: Jentadueto                                                                                                                    Average retail cost: $642/month

In Feb 2017 the FDA approved a once-daily combination of dapagliflozin 10 mg and saxagliptin 5 mg, as Qtern...Wikipedia

Manufacturer's Website: Qtern                                                                                                                               Average retail cost: $659/month

Sitagliptin/metformin (trade name Janumet) is an anti-diabetic drug, being a combination drug of sitagliptin (a dipeptidyl peptidase-4 inhibitor) and metformin...Wikipedia

Manufacturer's Website: Janumet                                                                                                                Average retail cost: $660/month

Ertugliflozin (trade name Steglatro) is a drug for the treatment of type 2 diabetes. In the United States, it was approved by the Food and Drug Administration for use as a monotherapy and as a fixed dose combination with either sitagliptin or with metformin. A combination with metformin is marketed as Segluromet and a combination with sitagliptin is marketed as Steglujan. ...Wikipedia

Manufacturer's Website: Steglujan                                                                                                                              Average retail cost: $660/month

Dapagliflozin is a drug of the gliflozin class, used to treat type 2 diabetes...Wikipedia

Manufacturer's Website: Xigduo                                                                                                                                 Average retail cost: $675/month

Synjardy (empagliflozin and metformin) is used to lower blood sugar and treat type 2 diabetes.

Manufacturer's Website: Synjardy                                                                                                                    Average retail cost: $716/month

Canagliflozin (trade name Invokana or Sulisent) is a medication used for the treatment of type 2 diabetes. It is of the gliflozin class or subtype 2 sodium-glucose transport (SGLT-2) inhibitors class...Wikipedia

Manufacturer's Website: Invokamet                                                                                                                     Average retail cost: $723/month

Empagliflozin/linagliptin is a drug combination used for the treatment of type II diabetes. It is a combination of empagliflozin and linagliptin. The combination preparation was developed and is marketed by Boehringer Ingelheim and Eli Lilly under the trade name Glyxambi...Wikipedia

Manufacturer's Website: Glyxambi                                                                                                                   Average retail cost: $769/month

Pioglitazone/metformin (also known by the brand names Actoplus Met, Piomet and Politor) is combination of two oral diabetes medications pioglitazone and metformin. The two oral antihyperglycemic agents with different mechanisms of action are used to improve glycemic control in patients with diabetes mellitus type 2...Wikipedia

Manufacturer's Website: Not Available                                                                                                        Average retail cost: $799/month

Insulin glargine/lixisenatide is a combination drug that combines insulin glargine and lixisenatide and is used as second-line treatment for diabetes...Wikipedia

Manufacturer's Website: Soliqua                                                                                                               Average retail cost: $1,026/month

Insulin glargine/lixisenatide is a combination drug that combines insulin glargine and lixisenatide and is used as second-line treatment for diabetes...Wikipedia

Manufacturer's Website: Xultophy                                                                                                                            Average retail cost: $1,485/kit

Empagliflozin/linagliptin/metformin, sold under the brand name Trijardy XR, is a drug combination used for the treatment of type 2 diabetes. It is a combination of empagliflozin, linagliptin, and metformin. Empagliflozin/linagliptin/metformin was approved for use in the United States in January 2020....Wikipedia

Manufacturer's Website: TrijardyXR                                                                                                     Average retail cost: $2,097/month

Synjardy (empagliflozin and metformin) is used to lower blood sugar and treat type 2 diabetes.

Manufacturer's Website: Synjardy                                                                                                                                 Average retail cost: $2,111/month

Canagliflozin (trade name Invokana or Sulisent) is a medication used for the treatment of type 2 diabetes. It is of the gliflozin class or subtype 2 sodium-glucose transport (SGLT-2) inhibitors class...Wikipedia

Manufacturer's Website: Invokamet                                                                                                                    Average retail cost: $2,162/month

Juvisync is no longer manufactured.

Metaglip is no longer manufactured.

Discontinued by manufacturer

PrandiMet (metformin/repaglinide)

Discontinued by manufacturer