*Prices reflect U.S. average retail price

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella elsewhere)[2] is a drug used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause. It has a black box warning about the risk of serious dehydration in children in the US; the most common adverse effects in others are gastrointestinal... Wikipedia

Manufacturer's Website: Linzess                                                                                                                               Average retail cost: $593/30 caps

Plecanatide (brand name Trulance), is a drug approved by the FDA for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP... Wikipedia

Manufacturer's Website: Trulance                                                                                                                                Average retail cost: $771/1 dose pack