Lysosomal Enzymes

*Prices reflect U.S. average retail price

Elaprase (idursulfase)

Idursulfase (brand name Elaprase), manufactured by Shire, is a drug used to treat Hunter syndrome (also called MPS-II). It is a purified form of the lysosomal enzyme iduronate-2-sulfatase and is produced by recombinant DNA technology in a human cell line... Wikipedia

 

Manufacturer's Website: Eleprase                                                                                                                      Average retail cost: $3,300/vial

Lumizyme (alglucosidase alfa)

Alglucosidase alfa (Lumizyme, Myozyme, Genzyme) is an enzyme replacement therapy (ERT) orphan drug for treatment of Pompe disease (Glycogen storage disease type II), a rare lysosomal storage disorder (LSD)... Wikipedia

 

Manufacturer's Website: Lumizyme                                                                                                                   Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Elelyso (taliglucerase alfa)

Taliglucerase alfa, commercially known as Elelyso, is a biopharmaceutical drug developed by Protalix and Pfizer. The drug, a recombinant glucocerebrosidase used to treat Gaucher's disease, was the first plant-made pharmaceutical to win approval by the U.S. Food and Drug Administration... Wikipedia

 

Manufacturer's Website: Elelyso                                                                                                                                 Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Cerezyme (imiglucerase)

Imiglucerase is a medication used in the treatment of Gaucher's disease.. Wikipedia

 

Manufacturer's Website: Cerezyme                                                                                                                               Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Aldurazyme (laronidase)

Iduronidase (EC 3.2.1.76, L-iduronidase, alpha-L-iduronidase, laronidase) is an enzyme with the systematic name glycosaminoglycan alpha-L-iduronohydrolase. This enzyme catalyses the hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate.. Wikipedia

 

Manufacturer's Website: Alduazyme                                                                                                                               Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Myozyme (alglucosidase alfa)

No longer available in United States.

 

Manufacturer's Website: Myozyme                                                                                                                              Average retail cost: $1,026/vial

Vimizim (elosulfase alfa)

Elosulfase alfa (trade name Vimizim) is a drug for the treatment of Morquio syndrome which is caused by a deficiency in the enzyme N-acetylgalactosamine-6-sulfatase. Elosulfase alfa is a synthetic version of this enzyme... Wikipedia

 

Manufacturer's Website: Vimizim                                                                                                                               Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

VPRIV (velaglucerase alfa)

Velaglucerase alfa (trade name VPRIV), manufactured by Shire plc is a hydrolytic lysosomal glucocerebroside-specific enzyme, which is a recombinant form of glucocerebrosidase indicated as a long-term enzyme replacement therapy for those suffering of Gaucher disease Type 1... Wikipedia

 

Manufacturer's Website: Vpriv                                                                                                                                     Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Naglazyme (galsulfase)

Arylsulfatase B (N-acetylgalactosamine-4-sulfatase, chondroitinsulfatase, chondroitinase, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase, EC 3.1.6.12) is an enzyme associated with mucopolysaccharidosis VI (Maroteaux–Lamy syndrome)... Wikipedia

 

Manufacturer's Website: Naglazyme                                                                                                             Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Fabrazyme (agalsidase beta)

The pharmaceutical company Genzyme produces synthetic agalsidase beta (INN) under the trade name Fabrazyme for treatment of Fabry disease.. Wikipedia

 

Manufacturer's Website: Not Available                                                                                                               Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Kanuma (sebelipase alfa)

Sebelipase alfa is a recombinant form of the enzyme lysosomal acid lipase (LAL) that was approved in 2015 under the tradename Kanuma in the US and EU for the treatment of people with lysosomal acid lipase deficiency (LAL-D).. Wikipedia

 

Manufacturer's Website: Kanuma                                                                                                                     Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Mepsevii (vestronidase alfa)

Vestronidase alfa-vjbk (trade name Mepsevii) is a drug for the treatment of Sly syndrome. It is a recombinant form of the human enzyme beta-glucuronidase. In the United States, it was approved in November 2017... Wikipedia

 

Manufacturer's Website:  Mepsevii                                                                                                                 Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Elfabrio (pegunigalsidase alfa-iwxj)

Pegunigalsidase alfa, sold under the brand name Elfabrio, is an enzyme replacement therapy for the treatment of Fabry disease... Wikipedia

 

Manufacturer's Website:  Fabrio                                                                                                                          Average retail cost: *

 

* This prescription is provided by your healthcare provider. It cannot be filled in a pharmacy and may be expensive.

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