Miscellaneous Coagulation Modifiers

*Prices reflect U.S. average retail price

Lysteda (tranexamic acid)

Tranexamic acid (TXA) is a medication used to treat or prevent excessive blood loss from major trauma, postpartum bleeding, surgery, tooth removal, nosebleeds, and heavy menstruation. It is also used for hereditary angioedema. It is taken either orally or injection into a vein....Wikipedia

 

 

Manufacturer's Website: Not Available                                                                                                        Average retail cost: $203/month

Koate-DVI (antihemophilic factor)

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

Manufacturer's Website: Koate-DVI                                                                                                                       Average retail cost: $343/dose

Amicar (aminocaproic acid)

AMINOCAPROIC ACID slows down or stops blood clots from being broken down. This medicine helps to prevent or treat excessive bleeding.

 

 

Manufacturer's Website: Not Available                                                                                                    Average retail cost: $788/30 tabs

Humate-P (antihemophilic factor / von willebrand factor )

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

Manufacturer's Website: Humate-P                                                                                                                    Average retail cost: $3,120/dose

Esperoct (antihemophilic factor)

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

Manufacturer's Website: Espercot                                                                                                                   Average retail cost: $3,310/kit

Afstyla (antihemophilic factor)

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

 

Manufacturer's Website: Afstyla                                                                                                                      Average retail cost: $3,830/kit

Advate (antihemophilic factor)

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

 

Manufacturer's Website: Advate                                                                                                                        Average retail cost: $12,782/dose

 

BeneFix (coagulation factor ix)

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia...Wikipedia

 

 

Manufacturer's Website: Benefix                                                                                                                Average retail cost: $13,537/dose

Eloctate (antihemophilic factor)

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

 

Manufacturer's Website: Elocate                                                                                                                  Average retail cost: $15,650/dose

Alprolix (coagulation factor ix)

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia...Wikipedia

 

 

Manufacturer's Website: Alprolix                                                                                                               Average retail cost: $15,697/dose

Xyntha (antihemophilic factor)

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

Manufacturer's Website: Xyntha                                                                                                                     Average retail cost: $37,912/dose

Tretten (factor XIII)

Catridecacog, sold under the brand name Tretten in the US and NovoThirteen in the EU) is a class of recombinant factor XIII A-subunit based biopharmaceutical medicine, indicated in patients with a rare clotting disorder, congenital factor XIII A-subunit deficiency, which is a kind of Factor XIII deficiency...Wikipedia

 

Manufacturer's Website: Tretten                                                                                                                        Average retail cost: $44,531/dose

Orladeyo (berotralstat)

Berotralstat, sold under the brand name Orladeyo, is a medication used to prevent attacks of hereditary angioedema (HAE) in people twelve years and older...Wikipedia

 

Manufacturer's Website: Orladeyo                                                                                                                   Average retail cost: $50,724/month

NovoSeven RT (coagulation factor via)

Recombinant factor VIIa (rFVIIa) also known as eptacog alfa (INN) is a form of blood factor VII that has been manufactured via recombinant technology. Brand names include NovoSeven among others...Wikipedia

 

Manufacturer's Website: NovoSeven RT                                                                                                         Average retail cost: $61,546/dose

Alphanine SD (coagulation factor ix)

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia...Wikipedia

 

 

Manufacturer's Website: Alphanine SD                                                                                                            Average retail cost: $70,692/month

 

Alphanate (antihemophilic factor / von willebrand factor)

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

 

Manufacturer's Website: Alphanate                                                                                                                   Average retail cost: *

 

* This prescription is provided by your healthcare provider. It cannot be filled in a pharmacy and may be expensive.

Berinert (C1 esterase inhibitor (human))

C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation but also as the major regulator of the contact system...Wikipedia

 

Manufacturer's Website: Berinert                                                                                                                                    Average retail cost: *

 

This drug is administered by your healthcare practitioner, which usually means it may be expensive.

 

Cyklokapron (tranexamic acid)

Tranexamic acid (TXA) is a medication used to treat or prevent excessive blood loss from major trauma, postpartum bleeding, surgery, tooth removal, nosebleeds, and heavy menstruation. It is also used for hereditary angioedema...Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                                Average retail cost: *

 

*This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Cinryze (C1 esterase inhibitor (human))

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

 

Manufacturer's Website: Cinryze                                                                                                                                  Average retail cost: *

 

*This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Defitelio (defibrotide)

Defibrotide, sold under the brandname Defitelio, is a mixture of single-stranded oligonucleotides that is purified from the intestinal mucosa of pigs. It is used to treat veno-occlusive disease of the liver of people having had a bone marrow transplant, with different limitations in the US and the European Union. It works by protecting the cells lining blood vessels in the liver and preventing blood clotting; the way it does this is not well understood...Wikipedia

 

Manufacturer's Website: Defitelio                                                                                                                          Average retail cost: *

 

*This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Hemlibra (femicizumab)

Emicizumab (trade name Hemlibra) is a humanized bispecific antibody for the treatment of haemophilia A, developed by Chugai (a subsidiary of Roche). A Phase I clinical trial found that it was well tolerated by healthy subjects...Wikipedia

 

Manufacturer's Website: Hemlibra                                                                                                                                     Average retail cost: *

 

This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Ixinity (coagulation factor ix)

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia...Wikipedia

 

 

Manufacturer's Website: Ixinity                                                                                                                                 Average retail cost: *

 

* This prescription is provided by your healthcare provider. It cannot be filled in a pharmacy and may be expensive.

Kalbitor (ecallantide)

Ecallantide (trade name Kalbitor) is a drug used for the treatment of hereditary angioedema (HAE) and in the prevention of blood loss in cardiothoracic surgery...Wikipedia

 

 

Manufacturer's Website: Kalbitor                                                                                                                                 Average retail cost: *

 

*This drug is administered by your healthcare practitioner, which usually means it may be expensive.

 

NovoEight (antihemophilic factor)

ANTIHEMOPHILIC FACTOR is used to prevent or control bleeding in patients with hemophilia A. This medicine is also used in these patients during surgery. Some products are used to treat von Willebrand's disease.

 

Manufacturer's Website: NovoEight                                                                                                                                Average retail cost: *

 

This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Obizur (antihemophilic factor)

Susoctocog alfa, sold under the brand name Obizur, is a medication used for the treatment of bleeding episodes in adults with acquired haemophilia, a bleeding disorder caused by the spontaneous development of antibodies that inactivate factor VIII...Wikipedia

 

Manufacturer's Website: Obizur                                                                                                                                     Average retail cost: *

 

* This prescription is provided by your healthcare provider. It cannot be filled in a pharmacy and may be expensive.

Rebinyn (coagulation factor ix)

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to haemophilia...Wikipedia

 

 

Manufacturer's Website: Rebinyn                                                                                                                                    Average retail cost: *

 

*This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Roctavian (valoctocogene roxaparvovec‐rvox)

Valoctocogene roxaparvovec, sold under the brand name Roctavian, is a gene therapy used for the treatment of hemophilia A... Wikipedia

 

 

Manufacturer's Website: Roctavian                                                                                                                                    Average retail cost: *

 

*This drug is administered by your healthcare practitioner, which usually means it may be expensive.

 

Ruconest (conestat alfa)

C1 ESTERASE INHIBITOR, RECOMBINANT helps to treat angioedema attacks.

 

 

Manufacturer's Website: Ruconest                                                                                                                                    Average retail cost: *

 

*This drug is only available at select specialty pharmacies, which usually means it may be expensive.

 

Takhzyro (lanadelumab)

Lanadelumab (INN; trade name Takhzyro) is a human monoclonal antibody (class IgG1 kappa) that targets plasma kallikrein (pKal) in order to promote prevention of angioedema in patients with hereditary angioedema...Wikipedia

 

Manufacturer's Website: Takhzyro                                                                                                                                Average retail cost: *

 

*This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Tavalisse (fostamatinib)

Fostamatinib, sold under the brand names Tavalisse and Tavlesse, is a tyrosine kinase inhibitor medication for the treatment of chronic immune thrombocytopenia (ITP)...Wikipedia

 

 

Manufacturer's Website: Tavalisse                                                                                                                                    Average retail cost: *

 

*This drug is only available at select specialty pharmacies, which usually means it may be expensive.

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