Interleukin Inhibitors

*Prices reflect U.S. average retail price

Siliq (brodalumab)

Brodalumab (trade name Siliq in the US and Kyntheum in Europe) is a human monoclonal antibody designed for the treatment of inflammatory diseases. In February 2017 it received US FDA approval to treat moderate to severe plaque psoriasis in people who have not improved with other treatments ...Wikipedia

 

Manufacturer's Website: Siliq                                                                                                                            Average retail cost: $10,417/3 cartons

Nucala (mepolizumab)

Mepolizumab, sold under the brand name Nucala, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis, and hypereosinophilic syndrome (HES). It recognizes and blocks interleukin-5 (IL-5), a signalling protein of the immune system... Wikipedia

 

Manufacturer's Website: Nucala                                                                                                                                 Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Simulect (basiliximab)

Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants... Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                                    Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Fasenra (benralizumab)

Influenza vaccines, also known as flu jabs or flu shots, are vaccines that protect against infection by influenza viruses. New versions of the vaccines are developed twice a year, as the influenza virus rapidly changes. While their effectiveness varies from year to year, most provide modest to high protection against influenza... Wikipedia

 

Manufacturer's Website: Fluarix                                                                                                                            Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Cosentyx (secukinumab)

Secukinumab, sold under the brand name Cosentyx, is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is marketed by Novartis for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis... Wikipedia

 

Manufacturer's Website: Cosentyx                                                                                                                         Average retail cost: $10,880/carton

Tremfya (guselkumab)

Guselkumab, sold under the brand name Tremfya, is a monoclonal antibody against interleukin-23 used for the treatment of plaque psoriasis... Wikipedia

 

Manufacturer's Website: Tremfya                                                                                                                            Average retail cost: $13,482/injection

Enspryng (satralizumab)

Satralizumab, sold under the brand name Enspryng, is a humanized monoclonal antibody medication that is used for the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune disease... Wikipedia

 

Manufacturer's Website: Enspryng                                                                                                                            Average retail cost: $16,952/syringe

Skyrizi (Risankizumab)

Risankizumab, sold under the brand name Skyrizi, is a humanized monoclonal antibody targeting interleukin 23A (IL-23A). Risankizumab is part of a collaboration between Boehringer Ingelheim and AbbVie. Risankizumab has been approved in the European Union, the United States, and Canada for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. In Japan, it is approved for treating plaque psoriasis, generalized pustular psoriasis, erythrodermic psoriasis and psoriatic arthritis in adults who have an inadequate response to conventional therapies... Wikipedia

 

Manufacturer's Website: Skyrizi                                                                                                                            Average retail cost: $31,632/package

Stelara (ustekinumab)

Ustekinumab, sold under the brand name Stelara is a monoclonal antibody medication developed by Janssen Pharmaceuticals, for the treatment of Crohn's disease, ulcerative colitis, plaque psoriasis and psoriatic arthritis... Wikipedia

 

Manufacturer's Website: Stelara                                                                                                                            Average retail cost: $29,283/syringe

Actemra (tocilizumab)

Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis and systemic juvenile idiopathic arthritis, a severe form of arthritis in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer... Wikipedia

 

Manufacturer's Website: Actemra                                                                                                                                    Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Arcalyst (rilonacept)

Rilonacept, sold under the brand name Arcalyst, is a medication used to treat cryopyrin-associated periodic syndromes, including familial cold autoinflammatory syndrome, and Muckle–Wells syndrome; deficiency of interleukin-1 receptor antagonist; and recurrent pericarditis ... Wikipedia

 

Manufacturer's Website: Arcalyst                                                                                                                        Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Cinqair (reslizumab)

The benefits with reslizumab are its ability to reduce the exacerbation rate and improve lung function and asthma-related quality of life in patients with severe eosinophilic asthma... Wikipedia

 

Manufacturer's Website: Cinqair                                                                                                                        Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Dupixent (dupilumab)

Dupilumab, sold under the brand name Dupixent, is a monoclonal antibody blocking interleukin 4 and interleukin 13, used for allergic diseases such as eczema (atopic dermatitis), asthma and nasal polyps which result in chronic sinusitis...Wikipedia

 

Manufacturer's Website: Dupixent                                                                                                                                     Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Ilaris (canakinumab)

Canakinumab (INN), sold under the brand name Ilaris, is a medication for the treatment of systemic juvenile idiopathic arthritis (SJIA) and active Still's disease, including adult-onset Still's disease (AOSD)... Wikipedia

 

Manufacturer's Website: Ilaris                                                                                                                        Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Ilumya (tildrakizumab)

Tildrakizumab (trade name Ilumya (US)/Ilumetri (European Union)) is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders. It is approved for the treatment of adult patients with moderate-to-severe plaque psoriasis in the United States and the European Union... Wikipedia

 

Manufacturer's Website: Ilumya                                                                                                                       Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Kevzara (sarilumab)

Sarilumab, sold under the brand name Kevzara, is a human monoclonal antibody medication against the interleukin-6 receptor. Regeneron Pharmaceuticals and Sanofi developed the drug for the treatment of rheumatoid arthritis... Wikipedia

 

Manufacturer's Website: Kevzara                                                                                                                        Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Kineret (anakinra)

Anakinra, sold under the brand name Kineret, is a biopharmaceutical medication used to treat rheumatoid arthritis, cryopyrin-associated periodic syndromes, familial Mediterranean fever, and Still's disease... Wikipedia

 

Manufacturer's Website: Kineret                                                                                                                        Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Sylvant (siltuximab)

Siltuximab (INN, trade name Sylvant; also known as CNTO 328, anti-IL-6 chimeric monoclonal antibody or cCLB8) is a chimeric (made from human and mouse proteins) monoclonal antibody. It binds to interleukin-6. Siltuximab has been investigated for the treatment of neoplastic diseases: metastatic renal cell cancer, prostate cancer, and Castleman's disease, among other types of cancer... Wikipedia

 

Manufacturer's Website: Sylvant                                                                                                                       Average retail cost: *

 

*Specialty drugs are often expensive and may need to be filled through specialty pharmacies.

Taltz (ixekizumab)

Ixekizumab, sold under the brand name Taltz, is an injectable medication for the treatment of autoimmune diseases. Chemically, it is a form of a humanized monoclonal antibody. The substance acts by binding interleukin 17A and neutralizing it, reducing inflammation... Wikipedia

 

Manufacturer's Website:Taltz                                                                                                                        Average retail cost: *

 

*Specialty drugs are often expensive and may need to be filled through specialty pharmacies.

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