Selective Immunosuppressants

*Prices reflect U.S. average retail price

CellCept (mycophenolate mofetil)

Mycophenolic acid (MPA) is an immunosuppressant medication used to prevent rejection following organ transplantation and to treat autoimmune conditions such as Crohn's disease and lupus. Specifically it is used following kidney, heart, and liver transplantation ...Wikipedia

 

Manufacturer's Website: CellCept                                                                                                                                     Average retail cost: $1,192/60 tabs

Myfortic (mycophenolic acid)

Mycophenolic acid (MPA) is an immunosuppressant medication used to prevent rejection following organ transplantation and to treat autoimmune conditions such as Crohn's disease and lupus. Specifically it is used following kidney, heart, and liver transplantation... Wikipedia

 

Manufacturer's Website: Not available                                                                                                                                Average retail cost: $950/60 tabs

Rapamune (sirolimus)

Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants ...Wikipedia

 

Manufacturer's Website: Rapamune                                                                                                                       Average retail cost: $1,267/30 tabs

Arava (leflunomide)

Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis... Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                Average retail cost: $1,873/30 tabs

Zortress (everolimus)

Everolimus, sold under the brand name Zortress among others, is a medication used as an immunosuppressant to prevent rejection of organ transplants and as a targeted therapy in the treatment of renal cell cancer and other tumours... Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                   Average retail cost: $1,538/60 tabs

Bafiertam (monomethyl fumarate)

Monomethyl fumarate, sold under the brand name Bafiertam is a medication for the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults... Wikipedia

 

Manufacturer's Website: Bafiertam                                                                                                                    Average retail cost: $6,984/120 tabs

Benlysta (belimumab)

Belimumab, sold under the brand name Benlysta, is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). It is approved in the United States, Canada, and the European Union to treat systemic lupus erythematosus... Wikipedia

 

Manufacturer's Website: Benlysta                                                                                                                            Average retail cost: $5,543/carton

Vumerity (diroximel fumarate)

Diroximel fumarate, sold under the brand name Vumerity, is a medication used for the treatment of relapsing forms of multiple sclerosis (MS)... Wikipedia

 

Manufacturer's Website: Vumerity                                                                                                                               Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Orencia (abatacept)

Abatacept, sold under the brand name Orencia, is a medication used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the immune activity of T cells. It is a modified antibody... Wikipedia

 

Manufacturer's Website: Orencia                                                                                                                      Average retail cost: $6,510/carton

Mayzent (Siponimod)

Siponimod, sold under the brand name Mayzent, is a selective sphingosine-1-phosphate receptor modulator for oral use that is used for multiple sclerosis (MS). It is intended for once-daily oral administration ...Wikipedia

 

Manufacturer's Website: Mayzent                                                                                                                     Average retail cost: $9,760/30 tabs

Ponvory (ponesimod)

Ponesimod, sold under the brand name Ponvory, is a medication for the treatment of multiple sclerosis... Wikipedia

 

Manufacturer's Website: Ponvory                                                                                                                                Average retail cost: $9,446/30 tabs

Tecfidera (dimethyl fumarate)

Monomethyl fumarate, sold under the brand name Tecfidera is a medication for the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults ...Wikipedia

 

Manufacturer's Website: Not Available                                                                                                                  Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Nulojix (belatacept)

Belatacept, sold under the brand name Nulojix, is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4, which is a molecule crucial in the regulation of T cell costimulation, selectively blocking the process of T-cell activation. It is intended to provide extended graft and transplant survival while limiting the toxicity generated by standard immune suppressing regimens, such as calcineurin inhibitors... Wikipedia

 

Manufacturer's Website: Nulojix                                                                                                                                Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Veopoz (pozelimab- bbfg)

Pozelimab, sold under the brand name Veopoz, is a recombinant monoclonal antibody used for the treatment of CD55-deficient protein-losing enteropathy, also known as CHAPLE disease... Wikipedia

 

Manufacturer's Website: Veopoz                                                                                                                      Average retail cost: $34,615/vial

Afinitor Disperz (everolimus)

Everolimus, sold under the brand name Afinitor among others, is a medication used as an immunosuppressant to prevent rejection of organ transplants and as a targeted therapy in the treatment of renal cell cancer and other tumours... Wikipedia

 

Manufacturer's Website: Affintor                                                                                                                             Average retail cost: $35,669/56 tabs

Gilenya (fingolimod)

Fingolimod, sold under the brand name Gilenya, is an immunomodulating medication, mostly used for treating multiple sclerosis (MS). Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction. It has been reported to reduce the rate of relapses in relapsing-remitting multiple sclerosis by approximately one-half over a two-year period... Wikipedia

 

Manufacturer's Website: Gilenya                                                                                                                           Average retail cost: $13,791/30 caps

Afinitor (everolimus)

Everolimus, sold under the brand name Afinitor among others, is a medication used as an immunosuppressant to prevent rejection of organ transplants and as a targeted therapy in the treatment of renal cell cancer and other tumours... Wikipedia

 

Manufacturer's Website: Affintor                                                                                                                               Average retail cost: $20,942/28 tabs

Arzerra (ofatumumab)

Ofatumumab is a fully human monoclonal antibody to CD20, which appears to inhibit early-stage B lymphocyte activation. Under the brand name Arzerra, it is approved for the treatment of certain types of chronic lymphocytic leukemia (CLL) in the United States. Under the brand name Kesimpta, it is approved for the treatment of multiple sclerosis in the United States as well as in the EU and other regions... Wikipedia

 

Manufacturer's Website: Arzerra                                                                                                                            Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive. It is not covered by most Medicare and insurance plans

Aubagio (teriflunomide)

Teriflunomide, sold under the brand name Aubagio, is the active metabolite of leflunomide. Teriflunomide was investigated in the Phase III clinical trial TEMSO as a medication for multiple sclerosis (MS). The study was completed in July 2010. 2-year results were positive. However, the subsequent TENERE head-to-head comparison trial reported that "although permanent discontinuations [of therapy] were substantially less common among MS patients who received teriflunomide compared with interferon beta-1a, relapses were more common with teriflunomide." The drug was approved for use in the United States in September 2012 and for use in the European Union in August 2013... Wikipedia

 

Manufacturer's Website: Aubagio                                                                                                                      Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Empaveli (pegcetacoplan)

Pegcetacoplan, sold under the brand name Empaveli among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH) ...Wikipedia

 

Manufacturer's Website: Empaveli                                                                                                                                     Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Entyvio (vedolizumab)

Vedolizumab, sold under the brand name Entyvio, is a monoclonal antibody medication developed by Millennium Pharmaceuticals, Inc. for the treatment of ulcerative colitis and Crohn's disease... Wikipedia

 

Manufacturer's Website: Entyvio                                                                                                                                Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Kesimpta (ofatumumab)

Ofatumumab under the brand name Kesimpta, it is approved for the treatment of multiple sclerosis in the United States as well as in the EU and other regions...Wikipedia

 

Manufacturer's Website: Kesimpta                                                                                                                                     Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Olumiant (baricitinib)

Baricitinib, sold under the brand name Olumiant among others, is a drug for the treatment of rheumatoid arthritis (RA) in adults whose disease was not well controlled by tumor necrosis factor (TNF) inhibitors. It acts as an inhibitor of janus kinase (JAK), blocking the subtypes JAK1 and JAK2. The drug is approved for medical use in the European Union and in the United States. An important side effect of JAK inhibitors is serious bacterial, mycobacterial, fungal and viral infections... Wikipedia

 

Manufacturer's Website: Olumiant                                                                                                                              Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Rezurock (belumosudil)

Belumosudil, sold under the brand name Rezurock among others, is a medication used for the treatment of chronic graft versus host disease (cGvHD)... Wikipedia

 

Manufacturer's Website: Rezurock                                                                                                                                Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Saphnelo (anifrolumab)

Anifrolumab, sold under the brand name Saphnelo, is a monoclonal antibody used for the treatment of systemic lupus erythematosus (SLE)... Wikipedia

 

Manufacturer's Website: Saphnelo                                                                                                                                Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Soliris (eculizumab)

Eculizumab, sold under the brand name Soliris among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis, and neuromyelitis optica... Wikipedia

 

Manufacturer's Website: Soliris                                                                                                                            Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Syfovre (pegcetacoplan)

Pegcetacoplan, sold under the brand name Empaveli, among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria] and geographic atrophy of the retina... Wikipedia

 

Manufacturer's Website: Syfovre                                                                                                                            Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Tavneos (avacopan)

Avacopan, sold under the brand name Tavneos, is a medication used to treat anti-neutrophil cytoplasmic autoantibody-associated vasculitis ... Wikipedia

 

Manufacturer's Website: Tavneos                                                                                                                            Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Tezspire (tezepelumab)

Thalidomide, sold under the brand names Contergan, Thalomid among others, is a medication used to treat a number of cancers (including multiple myeloma), graft-versus-host disease, and a number of skin conditions including complications of leprosy. While it has been used in a number of HIV-associated conditions, such use is associated with increased levels of the virus... Wikipedia

 

Manufacturer's Website: Tezspire                                                                                                                      Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Tysabri (natalizumab)

Natalizumab, sold under the brand name Tysabri among others, is a medication used to treat multiple sclerosis and Crohn's disease ...Wikipedia

 

Manufacturer's Website: Tysabri                                                                                                                                     Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Ultomiris (ravulizumab)

Ravulizumab, sold under the brand name Ultomiris, is a humanized monoclonal antibody complement inhibitor medication designed for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome... Wikipedia

 

Manufacturer's Website: Ultomiris                                                                                                                                Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Uplizna (inebilizumab)

Inebilizumab, sold under the brand name Uplizna, is a medication for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adults ...Wikipedia

 

Manufacturer's Website: Uplizna                                                                                                                                     Average retail cost: *

 

* This drug is administered by your healthcare practitioner, which usually means it may be expensive.

Xolair (omalizumab)

Omalizumab, sold under the brand name Xolair, is a medication used to treat asthma, nasal polyps, and urticaria... Wikipedia

 

Manufacturer's Website: Xolair                                                                                                                                Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

Zeposia (ozanimod)

Ozanimod, sold under the brand name Zeposia, is an immunomodulatory medication for the treatment of relapsing multiple sclerosis and ulcerative colitis... Wikipedia

 

Manufacturer's Website: Zeposia                                                                                                                                Average retail cost: *

 

* This drug is only available at select specialty pharmacies, which usually means it may be expensive.

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